Alendronate-eluting polyglucose-lignol composite (POGLICO)

Figures & data

Figure 1. A POGLICO-SHS implant (birch screw).

Figure 2. MicroCT results. A. POGLICO-SHS-UNTR tibia (birch nail, no bisphosphonate). B. POGLICO-SCS-UNTR tibia (birch screw, no bisphosphonate). Note the screw-shaped layer of new bone indicating the implant surface. C. POGLICO-SHS-ALN+ tibia (birch nail, bisphosphonate-treated). Note the increased thickness of the surrounding bone.

Figure 3. Bone density in the vicinity of the implant.

Figure 4. Histology of POGLICO-SHS-UNTR tibia (birch nail, no bisphosphonate). Note the layer of new bone covering the wood.

Results from mechanical testing and microCT

	n	Remaining in situ	Peak pullout force, N	Stiffness at pullout, N/mm	Bone density around nail, BV/TV	Bone density around nail, BMD
Saline	6	6	38.3	7.3	0.084 (0.051)	0.23 (0.067)
Alendronate	6	6	35.8	4.0	0.24 (0.056)	0.43 (0.060)
p-value		0.001 ^a	0.5	0.3	< 0.001	< 0.001

^a As compared to falling out.