Association between TP53 gene Arg72Pro polymorphism and idiopathic infertility in southeast Chinese Han males

Figures & data

Table 1. Characteristics of 745 male participants.

Variables	Cases	Azoospermia	Severe oligozoospermia	Control
	n = 361	n = 212	n = 149	n = 384
Age (years)	29.12 ± 3**	28.57 ± 2.91**	29.91 ± 2.98	30.45 ± 3.25
Cigarette smoking
Yes	157(43.49%) **	93(43.87%) **	64(42.95%) **	93(24.22%)
No	204(56.51%)	119(56.13%)	85(57.05%)	291(75.78%)
Drinking status
Yes	64(17.73%)	44(20.75%)	20(13.42%)	57(14.84%)
No	297(82.27%)	168(79.25%)	129(86.58%)	327(85.16%)
Radioactivity
Yes	79(21.88%)*	49(23.11%)*	30(20.13%)	52(13.54%)
No	282(78.12%)	163(76.89%)	119(79.87%)	332(86.46%)
High temperature
Yes	60(16.62%)	35(16.51%)	25(16.78%)	53(13.8%)
No	301(83.38%)	177(83.49%)	124(83.22%)	331(86.2%)
Serum hormones
FSH (mIU ml-1)	10.43 ± 8.51**	12.84 ± 9.94**	7 ± 3.88	6.85 ± 3.84
LH (mIU ml-1)	6.36 ± 4.34*	6.49 ± 4.79*	6.17 ± 3.61	5.64 ± 4.3
T (ng ml-1)	4.37 ± 2.14	4.36 ± 2.36	4.38 ± 1.8	4.43 ± 1.14
PRL (ng ml-1)	15 ± 7.03*	15.22 ± 7.1*	14.6 ± 6.94	13.75 ± 4.08
E2 (pg ml-1)	28.07 ± 11.2	29.12 ± 13.27	26.58 ± 7.1	27.46 ± 6.43
Semen parameters
Sperm density (×10^6 ml^−1)	1.29 ± 1.77**	0**	3.14 ± 1.35**	74.72 ± 52.22
Ejaculate volume (ml)	3.58 ± 1.1	3.55 ± 1.11	3.63 ± 1.1	3.65 ± 1.1

FSH: follicle-stimulating hormone; LH: luteinizing hormone; T: testosterone; PRL: prolactin; E_2: estradiol; *P value < 0.05;

**P value < 0.001. Values are expressed as mean ± s.d.—

Table 2. Genotype distribution and relative allele frequencies of the TP53 genotypes in 361 cases and 384 controls.

		Cases	Azoospermia	Severe oligozoospermia	Control
		n = 361	n = 212	n = 149	n = 384
	GG	136(37.67%)	82(38.68%)	54(36.24%)	112(29.17%)
Genotype	GC	165(45.71%)	101(47.64%)	64(42.95%)	180(46.87%)
	CC	60(16.62%)	29(13.68%)	31(20.81%)	92(23.96%)
	P value*	0.011	0.004	0.28	—
	Chi^2*	9.01	10.923	2.548	—
Allele	G	437(60.53%)	265(62.5%)	172(57.72%)	404(52.6%)
	C	285(39.47%)	159(37.5%)	126(42.28%)	364(47.4%)
	P value*	0.002	0.001	0.133	—
	Chi^2*	9.5	10.864	2.261	—
dominant mode	GG + GC	301(83.38%)	183(86.32%)	NS**	292(76.04%)
	P value*	0.013	0.003	NS**	—
	Chi^2*	6.169	8.92	NS**	—
	OR*	1.581	1.988	NS**	—
	95%CI*	1.1−2.272	1.26−3.138	NS**	—
recessive mode	GC + CC	225(62.33%)	130(61.32%)	NS**	272(70.83%)
	P value*	0.014	0.018	NS**	—
	Chi^2*	6.063	5.63	NS**	—
	OR*	1.468	1.532	NS**	—
	95%CI*	1.08-1.996	1.073-2.186	NS**	—

*vs. Control; **no significance