The ESR1 gene in unexplained recurrent spontaneous abortion

Figures & data

Table 1. Distribution of the ESR1 gene polymorphisms in URSA cases and controls.

	Polymorphism	Cases (%)	Controls (%)	x^2	p Value^a	OR(95% CI)
rs2234693
Allele	C	108 (41.9)	127 (34.7)	3.305	0.069	1.36 (0.98–1.88)
	T	150 (58.1)	239 (65.3)
Genotype	CC (%)	21 (16.3)	20 (10.9)
	CT (%)	66 (51.2)	87 (47.5)	3.461	0.177
	TT (%)	42 (32.6)	76 (41.5)
	Total	129	183
rs9340799
Allele	G (%)	91 (35.3)	78 (21.3)	14.933	0.00011	2.01 (1.41–2.88)
	A (%)	167 (64.7)	288 (78.7)
Genotype	GG (%)	25 (19.4)	14 (7.7)
	AG (%)	41 (31.8)	50 (27.3)	12.244	0.002
	AA (%)	63 (48.8)	119 (65.0)
	Total	129	183
	AG + GG (%)	66 (51.2)	64 (35.0)	8.160	0.004	1.95 (1.23–3.09)
	AA (%)	63 (48.8)	119 (65.0)
	AG + AA (%)	104 (80.6)	169 (92.3)	9.518	0.002	2.90 (1.44–5.83)
	GG (%)	25 (19.4)	14 (7.7)

^aEvaluated by x² test in comparison with the control group. ESR1: estrogen receptor 1; URSA: unexplained recurrent spontaneous abortion.

Table 2. Haplotype frequency of the ESR1 gene polymorphisms in URSA cases and controls.

Haplotype	Case (n = 129)	Control (n = 183)	x^2	p Value^a	p Value^b	OR(95% CI)
T-A	0.491	0.609	8.568	0.003	0.016	0.62 (0.45–0.86)^c
C-G	0.262	0.169	7.973	0.004	0.022	1.76 (1.19–2.59)^d
C-A	0.156	0.178	0.497	0.480	0.878
T-G	0.091	0.044	5.522	0.018	0.078

^aEvaluated by x² test in comparison with the control group; ^bEvaluated by 10⁴ permutation test; ^cT-A vs. C-G + C-A + T-G; ^dC-G vs. T-A + C-A + T-G. ESR1: estrogen receptor 1; URSA: unexplained recurrent spontaneous abortion.