Placebo-controlled study with OHIO chamber of prophylactic pranlukast for children with Japanese cedar pollinosis: TOPIC-J III study

Figures & data

Figure 1. Study schedule. ECP, eosinophil cationic protein; JC, Japanese cedar.

Table 1. Nasal symptoms questionnaire.

Sneezing – ‘How severe is sneezing?’

0: None/1: Mild/2: Moderate/3: Severe/4: Very severe

Nasal discharge – ‘How severe is running nose?’

0: None/1: Mild/2: Moderate/3: Severe/4: Very severe

Nasal obstruction – ‘How severe is nasal obstruction?”

0: None/1: Mild/2: Moderate/3: Severe/4: Very severe

Table 2. Patient characteristics at baseline.

	Pranlukast hydrate group	Placebo group
No. of patients	13	12
Sex
Male	6 (46.2%)	4 (33.3%)
Female	7 (53.8%)	8 (66.7%)
Age, years
12	3 (23.1%)	1 (8.3%)
13	1 (7.7%)	5 (41.7%)
14	5 (38.5%)	3 (25%)
15	4 (30.8%)	3 (25%)
Mean ± SD	13.77 ± 1.17	13.67 ± 0.98
CAP-RAST
Class 3	0	1 (8.3%)
Class 4	0	1 (8.3%)
Class 5	1 (7.7%)	1 (8.3%)
Class 6	12 (92.3%)	9 (75%)

Table 3. Mean symptom scores in the first before pollen exposure in the OHIO chamber.

	Pranlukast hydrate group (mean ± standard error)	Placebo group (mean ± standard error)	U-test
Sneezing	0.582 ± 0.222	0.583 ± 0.205	p = 1.000
Rhinorrhea	1.110 ± 0.255	0.893 ± 0.248	p = 0.566
Nasal obstruction	1.011 ± 0.261	0.667 ± 0.239	p = 0.393
Total nasal symptoms	2.703 ± 0.603	2.143 ± 0.606	p = 0.369

Figure 2. Weekly mean sneezing scores. The solid line and dashed line represent the pranlukast hydrate group and the placebo group, respectively.

: significant,

: not significant. JC, Japanese cedar.

Figure 3. Weekly mean rhinorrhea scores. The solid line and dashed line represent the pranlukast hydrate group and the placebo group, respectively.

: significant,

: not significant. JC, Japanese cedar.

Figure 4. Weekly mean nasal obstruction scores. The solid line and dashed line represent the pranlukast hydrate group and the placebo group, respectively.

: significant,

: not significant. JC, Japanese cedar.

Figure 5. Weekly mean total nasal symptoms scores. The solid line and dashed line represent the pranlukast hydrate group and the placebo group, respectively.

: significant,

: not significant. JC, Japanese cedar.

Figure 6. Changes of eosinophil cationic protein.