Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles

This work was supported by the key scientific and technological projects of Shandong Province in 2008.

Figures & data

Figure 1. Synthetic scheme of CS-SA and GA-CS-SA.

Figure 2. ¹H NMR spectrum of SA, GA, CS, CS-SA, and GA-CS-SA.

Figure 3. Fluorescence intensity ratio (I₁/I₃) against the concentration of CS-SA and GA-CS-SA.

Table I. Physicochemical properties of GA-CS-SA and CS-SA.

Samples	SD (%)	CMC (μg/mL)	AN (±)	Diameter (nm)	Zeta (mv)
CS-SA(1:0.05)	4.1 ± 0.7	33.67 ± 0.43	1.75 ± 0.03	145.4 ± 2.1	25.7 ± 0.4
CS-SA(1:0.1)	7.4 ± 0.5	30.56 ± 0.35	1.81 ± 0.02	142.3 ± 1.8	24.1 ± 0.4
CS-SA(1:0.15)	10.5 ± 0.6	28.45 ± 0.33	1.85 ± 0.01	139.5 ± 1.6	23.3 ± 0.3
CS-SA(1:0.2)	12.8 ± 0.6	26.34 ± 0.52	1.90 ± 0.01	136.8 ± 2.0	22.1 ± 0.5
CS-SA(1:0.25)	14.8 ± 0.3	25.13 ± 0.67	1.93 ± 0.01	134.6 ± 1.3	21.0 ± 0.4
CS-SA(1:0.3)	16.2 ± 0.8	23.20 ± 0.56	1.96 ± 0.00	131.7 ± 2.1	19.7 ± 0.2
GA-CS-SA	5.6 ± 0.4	17.94 ± 0.48	2.09 ± 0.03	121.1 ± 1.9	17.2 ± 0.3

Figure 4. Plot of ln (I₀/I) of pyrene fluorescence against DPC concentration in the presence of 1.0 mg/mL CSO-SA and GA-CS-SA.

Figure 5. (a) The size distribution of CS-SA (1:0.3) micelles and (b) GA-CS-SA micelles.

Figure 6. (a) Transmission electron microscopic images of CS-SA micelles and (b) GA-CS-SA micelles.