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ORIGINAL ARTICLE

Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development and in vitro characterization

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Pages 928-936 | Received 14 Nov 2014, Accepted 12 Dec 2014, Published online: 31 Mar 2015

Figures & data

Figure 1. SEM images of (a) Drug-loaded nanofiber (b) Blank nanofiber.

Figure 1. SEM images of (a) Drug-loaded nanofiber (b) Blank nanofiber.

Figure 2. Swelling index of plain polymer, blank nanofibers, and drug-loaded nanofibers.

Figure 2. Swelling index of plain polymer, blank nanofibers, and drug-loaded nanofibers.

Figure 3. Diffractogram of (a) DIA powder (b) PLLA (c) DIA-loaded nanofiber.

Figure 3. Diffractogram of (a) DIA powder (b) PLLA (c) DIA-loaded nanofiber.

Figure 4. Solubility study of DIA powder and DIA loaded in PLLA nanofiber.

Figure 4. Solubility study of DIA powder and DIA loaded in PLLA nanofiber.

Figure 5. Tensile strength of (a) Blank PLLA nanofiber (b) Drug-loaded nanofiber.

Figure 5. Tensile strength of (a) Blank PLLA nanofiber (b) Drug-loaded nanofiber.

Figure 6. Mucoadhesive strength of (a) blank PLLA nanofiber (b) drug-loaded PLLA nanofiber.

Figure 6. Mucoadhesive strength of (a) blank PLLA nanofiber (b) drug-loaded PLLA nanofiber.

Figure 7. Release profiles of DIA from the DIA-loaded nanofibers.

Figure 7. Release profiles of DIA from the DIA-loaded nanofibers.

Figure 8. Plot of percent drug release and kinetic analysis using different kinetic models.

Figure 8. Plot of percent drug release and kinetic analysis using different kinetic models.

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