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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 44, 2016 - Issue 1
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ORIGINAL ARTICLE

Nanostructured lipid carriers as a potential vehicle for Carvedilol delivery: Application of factorial design approach

Ganesh B. PatilDepartment of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Maharashtra, India
,
Nandkishor D. PatilDepartment of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Maharashtra, India
,
Prashant K. DeshmukhDepartment of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Maharashtra, India
,
Pravin O. PatilDepartment of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Maharashtra, IndiaCorrespondence[email protected]
&
Sanjay B. BariDepartment of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Maharashtra, India
Pages 12-19 | Received 24 Dec 2013, Accepted 13 Mar 2014, Published online: 28 May 2014

Figures & data

Table I. Coded values of the independent variables for CAR-NLCs.

Table II. The 23 factorial design layouts.

Figure 1. FT-IR spectra of (A) CAR, (B) GMS, (C) placebo, and (D) NLCs.
Figure 1. FT-IR spectra of (A) CAR, (B) GMS, (C) placebo, and (D) NLCs.
Figure 2. DSC thermograms of CAR, placebo, and CAR loaded lyophilized NLCs.
Figure 2. DSC thermograms of CAR, placebo, and CAR loaded lyophilized NLCs.
Figure 3. SEM of CAR loaded NLCs optimized batch F5.
Figure 3. SEM of CAR loaded NLCs optimized batch F5.
Figure 4. XRD pattern of (1) Carvedilol, (2) NLCs, and (3) placebo.
Figure 4. XRD pattern of (1) Carvedilol, (2) NLCs, and (3) placebo.
Figure 5. In vitro drug release profile of CAR-NLCs (n = 3, mean ± SD).
Figure 5. In vitro drug release profile of CAR-NLCs (n = 3, mean ± SD).
Figure 6. Response surface plots showing the effect of total lipid (X1), and the effect of liquid lipid (X2), on particle size (Y1).
Figure 6. Response surface plots showing the effect of total lipid (X1), and the effect of liquid lipid (X2), on particle size (Y1).
Figure 7. Response surface plots showing the effect of total lipid (A), and the effect of liquid lipid (B), on EE% (Y2).
Figure 7. Response surface plots showing the effect of total lipid (A), and the effect of liquid lipid (B), on EE% (Y2).

Table III. Summary of ANOVA results for Y1 and Y2.

Table IV. Stability studies data of optimized CAR-NLCs formulation (F5).

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