Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin

Figures & data

Figure 1. Trends of levels in every factor.

Table I. Factors and levels.

Factors	Levels
	A dialysis time (h)	B volume ratio of the organic and aqueous	C concentration of CS-SA (mg/mL)	D ratio of drug/micelle solution (w/v)
1	1	1.5	2	15
2	2	2	3	20
3	3	2.5	4	25

Table II. Design and results of the orthogonal experiment.

NO.	A	B	C	D	EE (%)
1	1	1	1	1	56.3
2	1	2	2	2	65.5
3	1	3	3	3	61.3
4	2	1	2	3	63.6
5	2	2	3	1	62.7
6	2	3	1	2	61.3
7	3	1	3	2	60.5
8	3	2	1	3	61.6
9	3	3	2	1	60.8
K1	61.0	60.1	59.7	59.9
K2	62.5	63.3	63.3	62.4
K3	61.0	61.1	61.1	62.2
R	1.5	3.2	3.6	2.5

Table III. EE and diameter of OXA-CS-SA prepared by the optimal conditions.

Batch NO.	1	2	3	Mean ± s
EE (%)	66.8	67.1	66.9	66.9 ± 0.2
Diameter (nm)	190.4	185.3	193.6	189.8 ± 17.5

Figure 2. SEM photograph of CS-SA micelles and micelles with OXA.

Figure 3. The size distribution of CS-SA micelles and OXA-CS-SA micelles.

Figure 4. SEM photograph of GA-CS-SA micelles and OXA-GA-CS-SA micelles.

Figure 5. The size distribution of GA-CS-SA micelles and OXA-GA-CS-SA micelles.

Figure 6. In vitro release profiles of DOX, OXA-CS-SA and OXA-GA- CS-SA in PBS (pH = 7.4).

Figure 7. The concentrations in the tissues of mice at 0.5 h.

Figure 8. The concentrations in the tissues of mice at 4 h.

Figure 9. The concentrations in the tissues of mice at 12 h.