In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers

Figures & data

Figure 1. Schematic illustration of the formation, accumulation at tumor site, and drug delivery of the self-assembled Cur-loaded oHMN. Available in colour online.

Figure 2. The leakage rate (LR) of Cur-oHMN at different times.

Figure 3. The change of the mean particle size at different times.

Table I. Compatibility and stability of Cur-oHMN with the culture medium.

Time (h)	LR ± SD (%)	Size ± SD (nm)
0	0	61.8 ± 1.5
0.5	0.994 ± 0.024	64.9 ± 3.6
1	2.010 ± 0.179	63.7 ± 2.2
2	4.278 ± 0.345	64.8 ± 2.6
4	5.567 ± 0.289	64.2 ± 2.8
6	6.467 ± 0.315	66.1 ± 3.7
8	7.745 ± 0.285	67.5 ± 3.8
12	8.456 ± 0.274	72.9 ± 2.2

Figure 4. Fluorescent imaging of cellular uptake of Cur-HMN at different times after incubation with the A 785 cells. Available in colour online.

Figure 5. In vivo non-invasive NIRF images of free DiR (control) and DiR-labeled Cur-HMN (micelles) in mice, at 5 h. Available in colour online.

Figure 6. Time-dependent whole body images after intravenous injection in mice. Available in colour online.

Figure 7. In vivo non-invasive NIRF images of free DiR(control) and DiR labeled PCK micelles in nude mice at 6 h. Available in colour online.