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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 44, 2016 - Issue 3
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ORIGINAL ARTICLE

The efficacy of methylene blue encapsulated in silica nanoparticles compared to naked methylene blue for photodynamic applications

Ghaseb Naser MakhadmehPhysics Department, School of Physics, Universiti Sains Malaysia, Penang, Malaysia;NanoBiotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, MalaysiaCorrespondence[email protected]
,
Azlan Abdul AzizPhysics Department, School of Physics, Universiti Sains Malaysia, Penang, Malaysia;NanoBiotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia
&
Khairunisak Abdul RazakEngineering Department, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Penang, Malaysia;NanoBiotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia
Pages 1018-1022 | Received 11 Dec 2014, Accepted 13 Jan 2015, Published online: 24 Feb 2015

Figures & data

Figure 1. Size distribution of SiNP-encapsulated MB.
Figure 1. Size distribution of SiNP-encapsulated MB.
Figure 2. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (2.50 μM), and (b) Naked MB (25.0 μM).
Figure 2. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (2.50 μM), and (b) Naked MB (25.0 μM).
Figure 3. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (1.25 μM), and (b) Naked MB (12.5 μM).
Figure 3. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (1.25 μM), and (b) Naked MB (12.5 μM).
Figure 4. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (0.63 μM), and (b) Naked MB (6.3 μM).
Figure 4. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (0.63 μM), and (b) Naked MB (6.3 μM).
Figure 5. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (0.31 μM), and (b) Naked MB (3.1 μM).
Figure 5. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (0.31 μM), and (b) Naked MB (3.1 μM).
Figure 6. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (0.16 μM), and (b) Naked MB (1.6 μM).
Figure 6. Changes in RBC spectra during irradiation with: (a) Encapsulated MB (0.16 μM), and (b) Naked MB (1.6 μM).
Figure 7. The reduction of the maximum peak for all samples: (a) Encapsulated MB, and (b) Naked MB.
Figure 7. The reduction of the maximum peak for all samples: (a) Encapsulated MB, and (b) Naked MB.
Figure 8. The normalization of maximum peak for all samples: (a) Encapsulated MB and (b) Naked MB.
Figure 8. The normalization of maximum peak for all samples: (a) Encapsulated MB and (b) Naked MB.
Figure 9. The relation between the half-life time of RBCs and the concentration of (a) Encapsulated MB, and (b) Naked MB.
Figure 9. The relation between the half-life time of RBCs and the concentration of (a) Encapsulated MB, and (b) Naked MB.

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