Cisplatin release from dual-responsive magnetic nanocomposites

Figures & data

Figure 1. Chemical reaction for preparing P (NIPAAM-MAA-HEM) nanogel.

Figure 2. FTIR spectrum of a) P (NIPAAM-MAA-HEM) nanogel, and b) P (NIPAAM-MAA-HEM) drug-loaded magnetic hydrogel nanocomposite.

Figure 3. NMR spectrum of P (NIPAAM-MAA-HEM) nanogel.

Table I. Swelling behavior of the nanogel at different values of pH and temperature.

Temperature (°C)	Q in pH of
	7.4	6.8	5.3
25	8.8	7.9	4.7
37	7.6	6.4	3.8
43	4.2	4	2.9

Figure 4. LCST chart for a) P (NIPAAM-MAA-HEM) nanogel, and b) P (NIPAAM-MAA-HEM) drug-loaded magnetic hydrogel nanocomposite.

Figure 5. EDX spectrum for P (NIPAAM-MAA-HEM) drug-loaded magnetic hydrogel nanocomposite.

Table II. Relation of drug-loading and cross-linker density.

Cross-linker content (wt.% of monomers)	Drug-loading
1%	6.8
3%	5.9
5%	4.2
1%	6.8
3%	5.9
5%	4.2

Figure 6. DLS chart for aqueous P (NIPAAM-MAA-HEM) drug-loaded magnetic hydrogel nanocomposite.

Figure 7. SEM micrograph of a) P (NIPAAM-MAA-HEM) nanogel, and b) P (NIPAAM-MAA-HEM) drug-loaded magnetic hydrogel nanocomposite.

Figure 8. Magnetic properties of a) Fe3O4 MNPs, and b) P (NIPAAM-MAA-HEM) drug-loaded hydrogel nanocomposite.

Table III. Cumulative release of cisplatin at a temperature of 25°C and pH of 7.4.

	Cumulative cisplatin release at 25°C
Time (hrs.)	24	48	72	96	168	216	264	288	336
Cumulative release (%)	16	19	21	22	27	28	30	30	31

Figure 9. Cumulative drug release from the magnetic hydrogel nanocomposite at a) 37°C and b) 43°C. Results are expressed as mean ± SD (n = 3).