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ORIGINAL ARTICLE

In vitro and in vivo evaluation of PEGylated nanoparticles of bendamustine for treatment of lung cancer

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Pages 1491-1497 | Received 19 Feb 2015, Accepted 14 May 2015, Published online: 01 Jul 2015

Figures & data

Figure 1. Particle size of PEGylated SLNs loaded with BM.

Figure 1. Particle size of PEGylated SLNs loaded with BM.

Figure 2. Zeta potential of PEGylated SLNs loaded with BM.

Figure 2. Zeta potential of PEGylated SLNs loaded with BM.

Table I. Physicochemical characterization of PEGylated SLNs.

Figure 3. Percentage cumulative drug release.

Figure 3. Percentage cumulative drug release.

Figure 4. Cytotoxicity assay of BM in the A-549 lung cancer cell line.

Figure 4. Cytotoxicity assay of BM in the A-549 lung cancer cell line.

Table II. Cytotoxicity MTT assay of SLNs in the A-549 lung cancer cell line.

Figure 5. Changes in tumor size during 28 days at different time intervals.

Figure 5. Changes in tumor size during 28 days at different time intervals.

Figure 6. Changes in tumor volume during 28 days at different time intervals.

Figure 6. Changes in tumor volume during 28 days at different time intervals.

Table III. Tumor mass and inhibition efficiency after treatment (Mean ± SD) (n = 5).

Table IV. Average size and volume of tumor during 21 days of treatment with PEGylated NPs of BM.

Figure 7. Tumor levels of BM at 4 and 24 h after drug treatment.

Figure 7. Tumor levels of BM at 4 and 24 h after drug treatment.

Figure 8. Plasma levels of BM at 4 and 24 h after drug treatment.

Figure 8. Plasma levels of BM at 4 and 24 h after drug treatment.

Table V. Stability studies of PEGylated SLNs.

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