Adult height and health-related quality of life after growth hormone therapy in small for gestational age subjects

Figures & data

Table 1.  Mapping height standard deviation scores (height SDS) into EQ-5D.

Height SDS	Mean EQ-5D score
Below <−3.00	0.6866
−3.00 to <−2.50	0.7440
−2.50 to <−2.00	0.8009
−2.00 to <−1.50	0.8194
−1.50 to <−1.00	0.8314
−1.00 to <−0.50	0.8505
−0.50 to <0.00	0.8638
0.00 to <0.50	0.8808
0.50 to <1.00	0.8874
1.00 to <1.50	0.8891
1.50 to <2.00	0.8986
2.00 to <2.50	0.9010
2.50 and above	0.9259

Table 2.  Baseline patient demographic characteristics.

Characteristic	GH treatment group
	0.033 mg/kg/day	0.067 mg/kg/day
n (male/female)	26 (22/4)	27 (16/11)
Birth data
Birth weight (g)	1841 (775)	1857 (765)
Birth weight SDS	−2.9 (1.3)	−2.7 (0.9)
Birth length (cm)	41.2 (5.1)	41.2 (5.7)
Birth length SDS	−3.9 (1.5)	−3.5 (1.4)
Gestational age (weeks)	37.2 (3.3)	36.5 (4.0)
Baseline data
Age at treatment start (years)	7.1 (2.2)	7.1 (2.4)
Bone age (years)	5.9 (2.2)	6.2 (2.8)
Height velocity (cm/year)	5.5 (0.7)	5.4 (1.4)
Height velocity SDS	−0.4 (1.3)	−0.8 (1.1)
Height (cm)	109 (13.0)	109 (13.8)
Height SDS	−3.2 (0.7)	−3.2 (0.7)
Bone age (years)	5.9 (2.2)	6.2 (2.8)
EQ-5D, baseline	0.726 (0.047)	0.726 (0.0407)

Data are shown as mean (SD).

Table 3.  Estimated height and EQ-5D scores at baseline and end of study.

Parameter	GH treatment group
	0.033 mg/kg/day	0.067 mg/kg/day
Height
Adult height SDS, mean (95% CI)	−1.8 (−2.1, −1.5)	−1.5 (−1.7, −1.2)
Δ Adult height SDS, mean (95% CI)	+1.4 (1.1, 1.6)	+1.7 (1.4, 2.0)
	p < 0.05	p < 0.05
HRQoL
EQ-5D, adult height, mean (95% CI)	0.837 (0.828; 0.846)	0.841 (0.829; 0.853)
EQ-5D, Change from baseline, mean (95% CI)	0.112 (0.092; 0.132)	0.115 (0.094; 0.136)
	p < 0.001	p < 0.001

Table 4.  Number of patients treated with growth hormone (GH), number (%) of patients achieving adult height, and mean body weight (kg) by treatment duration (years).

Treatment duration	Number of patients treated with GH, % (n)	Number of patients achieving adult height % (n)	Mean weight for treated children, kg (SD)
≤1 year	100 (53)	0 (0)	16.95 (5.1)
≤2 year	100 (53)	0 (0)	20.91 (5.9)
≤3 year	98.11 (52)	0 (0)	24.61 (7.1)
≤4 year	96.23 (51)	0 (0)	29.11 (8.6)
≤5 year	94.34 (50)	1.89 (1)	33.99 (10.2)
≤6 year	90.57 (49)	9.43 (5)	39.10 (11.0)
≤7 year	83.02 (46)	13.21 (7)	42.71 (10.6)
≤8 year	69.81 (37)	30.19 (16)	44.82 (10.7)
≤9 year	47.17 (30)	39.62 (21)	47.13 (10.2)
≤10 year	35.85 (20)	45.28 (24)	49.15 (8.5)
≤11 year	28.30 (16)	52.83 (28)	53.28 (8.2)
≤12 year	18.87 (11)	64.15 (34)	55.41 (8.2)
≤13 year	7.55 (6)	69.81 (37)	57.58 (8.6)
≤14 year	1.89 (1)	71.70 (38)	56.00 (NA)
≤15 year	0.00 (0)	71.70 (38)	NA