Cost of skeletal-related events in European patients with solid tumours and bone metastases: data from a prospective multinational observational study

Figures & data

Table 1. Cost of inpatient stays per SRE in Germany.

For each SRE, i = {pathologic fracture; … ; surgery to bone},

If DRG weighted average first day deductioni < LOS studyi < DRG weighted average first day additional chargei ;

costi = mean no. inpatient stays studyi × weighted average DRG costi .

If LOS studyi ≤ DRG weighted average first day deductioni ;

costi = mean no. inpatient stays studyi × [weighted average DRG costi − (DRG weighted average first day deductioni − LOS studyi) × DRG weighted average daily cost deductioni ].

If LOS studyi ≥ DRG weighted average first day additional chargei ;

costi = mean no. inpatient stays studyi × [weighted average DRG costi + (LOS studyi − DRG weighted average first day additional chargei) × DRG weighted average excess bed day costi ].

LOS, length of inpatient stay on study; no, number.

Table 2. Cost of inpatient stays per SRE in Italy.

For each SRE i = {pathologic fracture; … ; surgery to bone},

If LOS studyi ≤ weighted average DRG LOS thresholdi ;

costi = mean no. inpatient stays studyi × DRG costi .

If LOS studyi > weighted average DRG LOS thresholdi ;

costi = mean no. inpatient stays studyi × [weighted average DRG costi + (LOS studyi – weighted average DRG LOS thresholdi ) × weighted average DRG excess bed day costi ].

LOS, length of inpatient stay on study; no, number.

Table 3. Cost of inpatient stays per SRE in the UK.

For each SRE i = {pathologic fracture; … ; surgery to bone},

If mean LOS studyi < weighted average LOS HRGsi ;

costi = mean no. inpatient stays studyi × mean LOS studyi × weighted average daily cost HRGsi .

If mean LOS studyi ≥ weighted average LOS HRGsi ;

costi = mean no. inpatient stays studyi × [(weighted average LOS HRGsi × weighted average daily cost HRGsi ) + excess bed day costi × (mean LOS studyi – weighted average LOS HRGsi )].

LOS, length of inpatient stay on study; no, number.

Table 4. Cost of inpatient stays per SRE in Spain.

For each SRE i = {pathologic fracture; … ; surgery to bone}, and for each facility type f = {general unit/ward; … ; other };

costi = Σ mean no. facility stays studyf × mean duration facility stays studyf × per diem cost facilityf .

no, number.

Figure 1. Number of skeletal-related events by country and event type included in the health resource utilization analysis and cost analysis. NVF, non-vertebral fracture; RB, radiation to bone; SB, surgery to bone; SCC, spinal cord compression; SRE, skeletal-related event; VF, vertebral fracture.

Figure 2. Number of inpatient stays per skeletal-related event type by country. Data are shown as mean + standard deviation. n = total number of SREs of each type included in the health resource utilisation analysis. NVF, non-vertebral fracture; RB, radiation to bone; SB, surgery to bone; SCC, spinal cord compression; SRE, skeletal-related event; VF, vertebral fracture.

Figure 3. Duration of stays per inpatient stay by skeletal-related event type and country. Data are shown as mean + standard deviation. n = total number of inpatient stays by SRE type. NVF, non-vertebral fracture; RB, radiation to bone; SB, surgery to bone; SCC, spinal cord compression; SRE, skeletal-related event; VF, vertebral fracture.

Table 5. Mean cost per skeletal-related event in solid tumours.

Skeletal-related event	Mean cost per skeletal-related event (€)
	Germany	Italy	Spain	UK*
Non-vertebral fracture	1720	2087	3209	2254
Vertebral fracture	2124	2142	6968	1015
Radiation to bone	1694	2461	2378	704
Spinal cord compression	5847	4884	7903	12,082
Surgery to bone	9407	3348	4263	7447

*Costs in Great British Pounds Sterling were converted into Euros (£1 = €1.128,67).

Figure 4. Mean cost breakdown by skeletal-related event and health resource utilization type by country. NVF, non-vertebral fracture; RB, radiation to bone; SB, surgery to bone; SCC, spinal cord compression; VF, vertebral fracture.