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Original Article

Health resource use and costs of vilazodone and other selective serotonin re-uptake inhibitors in treating major depressive disorder

, , , , &
Pages 919-929 | Accepted 09 Jun 2015, Published online: 06 Jul 2015

Figures & data

Figure 1. Sample selection flowchart for patients with MDD treated with vilazodone or other SSRIs between 2010 and 2012. * The date of the earliest prescription claim on or after September 1, 2011, for citalopram, escitalopram, fluoxetine, paroxetine, sertraline, or vilazodone, whichever occurred first, was defined as the index date (with a 12-month wash-out period prior), and the antidepressant filled on that date was defined as the index drug. † Patients did not use any second-generation antidepressant or antipsychotic other than the index drug within 2 weeks after the index date. Second-generation antidepressants included SSRIs, SNRIs, bupropion, nefazodone, trazodone, and mirtazapine. ‡ Patients receiving fluvoxamine as the index drug were excluded from the analysis due to small sample size. MDD, major depressive disorder; SNRI, serotonin and norepinephrine re-uptake inhibitor; SSRI, selective serotonin re-uptake inhibitor.

Figure 1. Sample selection flowchart for patients with MDD treated with vilazodone or other SSRIs between 2010 and 2012. * The date of the earliest prescription claim on or after September 1, 2011, for citalopram, escitalopram, fluoxetine, paroxetine, sertraline, or vilazodone, whichever occurred first, was defined as the index date (with a 12-month wash-out period prior), and the antidepressant filled on that date was defined as the index drug. † Patients did not use any second-generation antidepressant or antipsychotic other than the index drug within 2 weeks after the index date. Second-generation antidepressants included SSRIs, SNRIs, bupropion, nefazodone, trazodone, and mirtazapine. ‡ Patients receiving fluvoxamine as the index drug were excluded from the analysis due to small sample size. MDD, major depressive disorder; SNRI, serotonin and norepinephrine re-uptake inhibitor; SSRI, selective serotonin re-uptake inhibitor.

Table 1. Baseline characteristics of patients treated with vilazodone vs other SSRIs†,‡.

Table 2. Comparison of 6-month healthcare resource utilization between SSRIs and vilazodone; unadjusted incidence rates (per 100 patients).

Table 3. Comparison of 6-month healthcare resource utilization between SSRIs and vilazodone; adjusted incidence rate ratios (95% CI) vs vilazodone†,‡.

Table 4. Comparison of 6-month healthcare costs between SSRIs and vilazodone; average healthcare costs (mean ± SD).

Table 5. Comparison of 6-month healthcare costs between SSRIs and vilazodone; adjusted difference in average healthcare costs (95% CI) vs vilazodone†,‡,$.

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