Cost of skeletal complications from bone metastases in six European countries

Figures & data

Figure 1. Study design and data collection for patients with one SRE (a) and multiple SREs (b).

Table 1. Patient baseline clinical and demographic characteristics.

	Austria (n = 57)	Czech Republic (n = 59)	Finland (n = 60)	Greece (n = 59)	Portugal (n = 59)	Sweden (n = 62)
Mean age, years	59.6	64.5	65.7	60.5	61.9	70.0
Female, n (%)	42 (74)	32 (54)	16 (27)	19 (32)	21 (36)	16 (26)
Geriatric age group, n (%)
<65 years	35 (61)	26 (44)	29 (48)	33 (56)	35 (59)	19 (31)
≥65 years	22 (39)	33 (56)	31 (52)	26 (44)	24 (41)	43 (69)
≥75 years	5 (9)	9 (15)	10 (17)	4 (7)	8 (14)	22 (35)
Number of SREs (% of SREs)
Radiation to bone	57 (44)	59 (45)	60 (51)	59 (49)	59 (47)	62 (52)
Pathologic fracture
Long bone	25 (19)	18 (4)	8 (7)	8 (7)	14 (11)	9 (8)
Other bone	22 (17)	33 (25)	30 (26)	32 (26)	29 (23)	27 (23)
Surgery to bone	17 (13)	10 (8)	9 (8)	12 (10)	12 (10)	11 (9)
Spinal cord compression	10 (8)	10 (8)	10 (9)	10 (8)	12 (10)	10 (8)
ECOG status,^a n (%)
0	18 (51)	5 (9)	3 (6)	8 (17)	3 (8)	7 (20)
1	13 (37)	35 (61)	25 (53)	25 (53)	23 (59)	10 (29)
2	4 (11)	15 (26)	12 (25)	12 (25)	9 (23)	13 (37)
3	0 (0)	2 (4)	7 (15)	2 (4)	3 (8)	5 (14)
4	0 (0)	0 (0)	0 (0)	0 (0)	1 (3)	0 (0)
Unknown	22 (–)	2 (–)	13 (–)	12 (–)	20 (–)	27 (–)
Primary tumor diagnosis, n (%)n (%)
Breast cancer	36 (63)	30 (51)	10 (17)	15 (25)	13 (22)	5 (8)
Lung cancer	11 (19)	4 (7)	4 (7)	34 (58)	30 (51)	3 (5)
Prostate cancer	2 (4)	25 (42)	34 (57)	5 (8)	15 (25)	33 (53)
Multiple myeloma	8 (14)	0 (0)	12 (20)	5 (8)	1 (2)	21 (34)
SRE status, n (%)
Single	53 (93)	54 (92)	35 (58)	47 (80)	53 (90)	31 (50)
Multiple	4 (7)	5 (8)	25 (42)	12 (20)	6 (10)	31 (50)
Time since diagnosis of bone metastases, months
n	43	59	48	53	56	41
Mean	9.78	12.69	17.27	5.83	4.88	16.79
Median	2.10	4.47	5.13	1.84	1.31	11.27
Bone metastases sites,^a n (%)
1–2	47 (96)	40 (68)	29 (60)	49 (91)	58 (100)	26 (63)
3–4	1 (2)	11 (19)	6 (13)	3 (6)	0 (0)	9 (22)
≥5	1 (2)	8 (14)	13 (27)	2 (4)	0 (0)	6 (15)
Missing	8 (–)	0 (–)	12 (–)	5 (–)	1 (–)	21 (–)

ECOG, Eastern Cooperative Oncology Group; SRE, skeletal-related event.

a Percentages calculated for the number of patients with available data.

Figure 2. Mean cost across countries by index SRE.

Figure 3. Mean cost per index SRE by country for radiation to bone (a), pathologic fracture (b), surgery to bone (c) and spinal cord compression (d)

Figure 4. Mean cost ratio by country and index SRE (a) and purchasing power parity adjusted mean cost ratio by country and SRE (b).