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Pharmacological Aspects

Major depression during interferon-α treatment: vulnerability and prevention

Depresión mayor durante el tratamiento con α-interferón: vulnerabilidad y prevención

Dépression majeure au cours d'un traitement par interféron-α: ulnérabilité et prévention

Pages 417-425 | Published online: 01 Apr 2022

Figures & data

Table I. Comparison of Major Depressive Disorder (MDD) and interferon-a depressive disorder (IFN-MDD) during interferon-a treatment.

Table II. Studies examining prevention of IFN-MDD using antidepressants. Three randomized placebo-controlled trials (RCT), and four open-label studies examining the prevention of major depressive disorder (MDD), diagnosed using criteria from the Diagnostic and Statistical Manual of Mental Disorders-IV (DMS-IV), the Hamilton Depression rating scale (HAM-D), or the Montgomery-Asberg Depression Rating Scale (MADRS).