714
Views
9
CrossRef citations to date
0
Altmetric
Report

Factorial design-based development of measlamine microspheres for colonic delivery

, , , &
Pages 182-188 | Published online: 01 Oct 2011

Figures & data

Figure 1. SEM photomicrographs of (A) uncoated microspheres (B) uncoated microspheres in groups (C) enteric-coated microspheres (D) T.S. of enteric-coated microspheres (E) enteric-coated micerospheres after dissolution.

Figure 1. SEM photomicrographs of (A) uncoated microspheres (B) uncoated microspheres in groups (C) enteric-coated microspheres (D) T.S. of enteric-coated microspheres (E) enteric-coated micerospheres after dissolution.

Table 2. Design of experiment

Table 3. Characterization of Microspheres

Figure 2. 3D graph of effect of drug polymer ratio and surfactant concentration on % yield.

Figure 2. 3D graph of effect of drug polymer ratio and surfactant concentration on % yield.

Figure 3. Interaction graph between drug polymer ratio and surfactant concentration.

Figure 3. Interaction graph between drug polymer ratio and surfactant concentration.

Figure 4. 3D graph of effect of drug: polymer ratio, stirring speed and surfactant on particle size

Figure 4. 3D graph of effect of drug: polymer ratio, stirring speed and surfactant on particle size

Figure 5. In vitro drug release profile of F14 formulation.

Figure 5. In vitro drug release profile of F14 formulation.

Table 4. Kinetic modeling of drug release of F14 formulation

Table1. Independent variables and levels (16)