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Review

The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease

, &
Article: e27321 | Received 21 Oct 2013, Accepted 22 Nov 2013, Published online: 10 Dec 2013

Figures & data

Figure 1. Structure of the human HP gene. The human HP2 allele arose by duplication of exons 3 and 4 of the HP1 allele. HP, Haptoglobin; kb, kilobase

Figure 1. Structure of the human HP gene. The human HP2 allele arose by duplication of exons 3 and 4 of the HP1 allele. HP, Haptoglobin; kb, kilobase

Figure 2. The structure of pre-HP1 and pre-HP2, and HP1 and HP2 is depicted on the right. It is also shown how the different proteins can be visualized on western blot (left side). (Adapted fromCitation8). HP, Haptoglobin; MW, molecular weight; kDa, kilo dalton

Figure 2. The structure of pre-HP1 and pre-HP2, and HP1 and HP2 is depicted on the right. It is also shown how the different proteins can be visualized on western blot (left side). (Adapted fromCitation8). HP, Haptoglobin; MW, molecular weight; kDa, kilo dalton

Table 1. Distribution of HP alleles and genotypes in healthy controls, CD and UC

Figure 3. Haptoglobin serum levels in healthy controls for each HP genotype. Values represent medians (lines) with their quartiles (upper and lower level box).

Figure 3. Haptoglobin serum levels in healthy controls for each HP genotype. Values represent medians (lines) with their quartiles (upper and lower level box).

Figure 4. Summary diagram of the different ways HP(2) can be involved in IBD pathogenesis. HP, Haptoglobin

Figure 4. Summary diagram of the different ways HP(2) can be involved in IBD pathogenesis. HP, Haptoglobin