Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis

Abstract

Conclusion. The results of our study demonstrated the association between the single nucleotide polymorphisms (SNPs) of GATA-3 and allergic rhinitis (AR). Objective. AR is considered to be controlled by T-helper type 2 (Th2) cells. GATA-3 is the crucial transcription factor controlling the differentiation and function of Th2 cells. We aimed to evaluate the association between the SNPs of GATA-3 and AR. Subjects and methods. GATA-3 SNPs in 109 AR patients and 112 healthy controls in China were detected with restriction fragment length polymorphism. Results. The genotypes at rs1269486 were GG, GA, and AA, and the genotypes at rs2229360 were CC, CT, and TT. The frequency of the G allele in the patient group was significantly higher than that in the control group (p<0.01), while the frequency of the A allele in the patient group was significantly lower than that in the control group (p<0.01). Meanwhile, the haplotype frequency of GC at the two loci in the patient group was significantly higher than that in the control group (p<0.01), and the haplotype frequency of AC in the patient group was significantly lower than that in the control group (p<0.01).

• Allergic rhinitis
• polymorphisms
• haplotype
• transcription factor
• GATA-3