The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure

Abstract

Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described.

Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy.

Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy.

Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration.

Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

Chinese abstract

背景：虽然有关于OK-432硬化疗法对甲状舌管囊肿（TDC）疗效的研究, 但其对该疗法后外科手术的影响尚未得到适当描述。

目的：本研究旨在描述TDC患者OK-432硬化治疗的预后因素, 并探讨其对OK-432硬化治疗反应差的患者的后续手术程序和组织学特征的影响。

材料和方法：我们对20例使用OK-432硬化疗法治疗的TDC患者的病历进行了回顾性分析。

结果：20例患者中, OK-432硬化治疗有效5例（25.0％）。 OK-432对多房囊肿的有效率（9.1％）低于单房囊肿（44.4％）, 尽管不显著。 OK-432硬化剂治疗后, 5例患者接受手术治疗。接受和没有接受OK-432硬化疗法的患者的手术时间和出血量没有显著差异。根据囊壁组织学检查结果, 2例患者出现层状鳞状上皮, 2例未见淋巴细胞浸润。

结论和意义：OK-432硬化疗法是TDC的一种可接受的初始治疗方法, 特别是对于单房囊肿, 因为对手术过程没有影响。

Keywords:

• OK432 sclerotherapy
• thyroglossal duct cyst
• surgical results

Disclosure statement

No potential conflict of interest was reported by the authors.