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Abstract
Background: Few studies have demonstrated the utility of pharyngeal interposition graft (PIG) applying pectoralis major myocutaneous flap (PMMCF) by comparing pharyngocutaneous fistula (PCF) rates.
Objective: The objective of this retrospective study was to clarify the utility of PIG applying PMMCF in reducing post-operative complications due to salvage total laryngectomy (STL).
Material and methods: STL was performed in 59 patients with recurrent laryngeal cancer after radiotherapy, comprising 37 non-PMMCF patients and 22 PMMCF patients. The primary endpoint was PCF rate. Comparisons were made between two groups: a group with simple closure not using PMMCF (non-PMMCF group), and the other with PMMCF used in a PIG (PMMCF group).
Results: PCF occurred in 15 of the 59 subjects (25.4%), including 13 of the 37 patients in the non-PMMCF group (35.1%) and 2 of the 22 patients in the PMMCF group (9.1%). PCF rate was significantly lower in the PMMCF group than in the non-PMMCF group (p = .033).
Conclusions and significance: We demonstrated that PIG applying PMMCF significantly reduced the PCF rate due to STL. In the future, surgeons need to conduct research focused on additional innovations to reduce post-operative complications as much as possible.
Chinese abstract
背景：很少有研究通过比较咽部皮肤瘘（PCF）的发生率来显示应用胸大肌肌皮瓣（PMMCF）行咽部间置移植（PIG）的有效性。
目的：回顾性研究应用胸大肌肌皮瓣（PMMCF）行咽部间置移植（PIG）在减少全喉切除术（STL）后并发症中的作用。
材料与方法：对59例喉癌放疗后复发患者进行STL术, 其中非PMMCF患者37例, PMMCF患者22例。主要终点是PCF发生率。比较两组：不使用PMMCF的简单关闭组（非PMMCF组）和使用PMMCF行PIG术组（PMMCF组）。
结果：59例患者中15例发生PCF（25.4%）, 其中非PMMCF组37例中有13例（35.1%）, PMMCF组22例中有2例（9.1%）。PMMCF组PCF发生率显著低于非PMMCF组（p = .033）。
结论及意义：应用PMMCF行PIG可显著降低STL所致PCF发生率。在未来, 外科医生需要进行更多的创新研究, 以尽可能减少术后并发症。
Disclosure statement
No potential conflicts of interest were reported by the authors.