Serum miR-632 is a potential marker for the diagnosis and prognosis in laryngeal squamous cell carcinoma

Abstract

Background: It has been demonstrated that miRNAs play critical roles in the tumorigenesis and progression of various tumors.

Objective: The purpose of this research was to determine the serum miR-632 levels in patients with laryngeal squamous cell carcinoma (LSCC) and to investigate its diagnostic and prognostic value.

Materials and methods: We detected serum miR-632 levels in 162 LSCC patients and 42 healthy volunteers. The ROC curve was carried out to determine diagnostic accuracy.

Results: We observed that serum miR-632 levels were upregulated in LSCC patients compared with healthy volunteers (p < .01). Subsequent results from ROC indicated that high sensitivity and specificity of serum miR-632 for diagnosing LSCC (area under the curve 0.8828). In addition, it was found that high expressions of serum miR-632 were significantly associated with advanced N stage (p = .020), histological grade (p = .001), and TNM stage (p = .014). Furthermore, patients with higher serum miR-632 expression had a shorter OS and DFS time than those with lower serum miR-632 levels.

Conclusion: Our data revealed that serum miR-632 may be a potential noninvasive biomarker which may become a potential diagnostic and prognostic biomarker for LSCC patients.

Chinese abstract

背景：经证明, miRNAs在多种肿瘤的发生、发展中起着重要作用。

目的：测定喉鳞状细胞癌（LSCC）患者血清miR-632水平, 探讨其诊断和预后价值。

材料与方法：检测了162例LSCC患者和42例健康志愿者的血清miR-632水平。绘制ROC曲线用于确定诊断的准确性。

结果：与健康志愿者相比, LSCC患者血清miR-632水平明显升高（p<.01）。ROC结果显示miR-632对LSCC的诊断具有较高的敏感性和特异性（曲线下面积0.8828）。此外, 还发现血清miR-632的高表达与晚期N期（p = .020）、组织学分级（p = .001）和TNM期（p = .014）显著相关。进而, 高血清miR-632表达的患者比低血清miR-632表达的患者有更短的OS和DFS时间。

结论：血清miR-632可能是一个潜在的无创性生物标志物, 有望成为LSCC患者的诊断和预后生物标志物。

Keywords:

• Serum miR-632
• laryngeal squamous cell carcinoma
• prognosis
• diagnosis

Disclosure statement

The authors declare that they have no conflict of interests.