Magnetic resonance imaging with intravenous gadoteridol injection based on 3D-real IR sequence of the inner ear in Meniere’s disease patient: feasibility in 3.5-h time interval

Abstract

Background

Intravenous gadoteridol injection can be applied to visualize endolymphatic hydrops (EH).

Aims/objectives

To explore whether 3.5-h time interval was feasible for clinical practice.

Materials and methods

We collected 70 unilateral Meniere’s disease (MD) patients who were divided into two groups randomly (group A: 3.5-h time interval; group B: 4-h time interval). Among the two groups, the signal intensity (SI) in perilymphatic area of the basal turn of cochlea, the results of visual evaluations in the vestibule, cochlea and semicircular canal and the detection results of EH were compared.

Results

Regarding the SI, no difference was found between A-affected ears and B-affected ears (p=.499), and no difference was found between A-unaffected ears and B-unaffected ears (p=.111). However, a difference was found between A-affected ears and A-unaffected ears (p=.005), and a difference was found between B-affected ears and B-unaffected ears (p=.012). Besides, no difference was found between the visual evaluations in the vestibule, cochlea, and semicircular canal of the two groups. Regarding the detection results of EH, no difference was found between the two groups (all p>.05).

Conclusions and significance

In the clinical application of gadoteridol for the inner ear, 3.5-h delayed MR imaging is feasible.

Chinese abstract

背景：静脉注射钆特醇可用于内淋巴水肿（EH）可视化。

目的：探讨 3.5 小时的时间间隔是否适用于临床实践。

材料和方法：我们召集了 70 名单侧梅尼埃病 (MD) 患者。这些患者被随机分为两组（A组：3.5小时时间间隔；B组：4小时时间间隔）。耳蜗基转外淋巴区的信号强度 (SI),、前庭、耳蜗和半规管目视评估结果以及EH检测结果, 在两组之间进行了比较。

结果： A组受影响的耳朵和 B组受影响的耳朵之间没有发现SI的差异（p ¼.499）, 并且在 A组 未受影响的耳朵和 B组未受影响的耳朵之间也没有发现差异（p ¼.111）。然而, 在 A组受影响的耳朵和 A组未受影响的耳朵之间发现了SI的差异（p ¼.005）, 在 B组受影响的耳朵和 B组未受影响的耳朵之间也发现了差异（p ¼.012）。此外, 在两组之间没有发现前庭、耳蜗和半规管的目视评估的差异。关于EH的检测结果, 两组之间没有发现差异（两组 p>.05）。

结论与意义：钆特醇内耳临床应用中, 3.5小时延迟磁共振成像是可行的。

Keywords:

• Magnetic resonance image
• 3.5 h
• gadoteridol
• Meniere’s disease

Acknowledgments

The authors thank Dr.Yang for the coordination and mentorship.

Disclosure statement

The authors stated that there was no potential conflict of interest. Wei Chen and Yue Geng designed and conducted research; Wei Chen and Naier Lin wrote the initial article; Sihui Yu and Yan Sha revised the article; Yan Sha had primary responsibility for the final content. Wei Chen and Yue Geng had the equal contributions to this manuscript and should be regarded as co-first authors. All authors read and approved the final manuscript.

Additional information

Funding

This study was supported by the Shanghai Municipal Science and Technology Commission Biomedicine Division Western Medicine Guidance Project under Grant [19411965700].