Sinonasal intestinal- and non-intestinal-type adenocarcinoma in China: a retrospective study of 14 cases

Abstract

Background

In China, reports on the epidemiology of adenocarcinomas of the nasal cavity and paranasal sinuses are limited.

Aim

This study aimed to describe the experience of a single institution in China in treating these malignant tumours.

Materials and Methods

We conducted a retrospective chart review of patients with adenocarcinoma of the nasal cavity and paranasal sinuses admitted between January 2019 and December 2021. Tumour staging was based on the American Joint Committee on Cancer, 8th edition, for sinonasal malignancies.

Results

The series included 10 men and 4 women (mean age, 54.5 [range, 14–80] years). Epistaxis and nasal obstruction were the most common clinical manifestations in 10 (71.4%) patients. Ten (71.4%) had stage T4 disease at diagnosis, but no patient had lymph node or distant metastasis. The posterosuperior septum (100.0%) and middle turbinate (92.8%) were the two sites most vulnerable to tumour invasion. All patients underwent endoscopic resection as the initial treatment; one patient died.

Conclusions and Significance

In China, these malignancies are related to exposure to certain substances; however, diagnosis can be delayed. Endoscopic resection is a suitable treatment option for adenocarcinomas of the nasal cavity and paranasal sinuses.

Chinese Abstract

背景：在中国, 关于鼻腔和鼻旁窦腺癌流行病学的报道是有限的。

目的：本研究旨在描述中国一家医疗机构在治疗这些恶性肿瘤方面的经验。

材料和方法：我们对2019 年 1 月至 2021 年 12 月期间入院的鼻腔和鼻旁窦腺癌患者进行了回顾性图表审查。肿瘤分期基于美国癌症联合委员会鼻窦恶性肿瘤第 8 版。

结果：共包括 10 名男性和 4 名女性（平均年龄为54.5岁 [范围, 14-80岁] ）。10例（71.4%）患者以鼻出血和鼻塞为最常见的临床表现。 10例(71.4%)患者 在诊断时已是 T4 期, 但没有患者有淋巴结或远处转移。 后上中隔 (100.0%) 和中鼻甲 (92.8%) 是最容易受到肿瘤侵袭的两个部位。 所有患者均接受内镜下切除术作为初始治疗； 一名患者死亡。

结论与意义：在中国, 这些恶性肿瘤与接触某些物质有关； 但是, 诊断可能会延迟。 内镜下切除是一种治疗鼻腔和鼻旁窦腺癌的合适选择。

Keywords:

• Sinonasal
• Adenocarcinoma
• Endoscopic resection
• Retrospective study
• China

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant number 81970856]; National Key Clinical Specialty Construction Project [grant number Z155080000004]; Shanghai Science and Technology Committee Foundation [grant number 21JC1401100]; Shanghai Xuhui District Science and Technology Committee Foundation [grant number 2021-008]; New Technologies of Endoscopic Surgery in Skull Base Tumor: CAMS Innovation Fund for Medical Sciences (CIFMS) [grant number 2019-I2M-5-003]; and Shanghai Sailing Program [grant number 21YF1405700].