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Abstract
Backgrounds
Larynx transplantation has been successfully performed four times, in 1998, 2010, 2015 and 2023 remained the ultimate goal of voice, feeding and breathing rehabilitation.
Objective
Immunosuppressive protocols used during the previous successful larynx allotransplantation are detailed.
Material and Methods
A systematic review of the literature on PUBMED/Medline, Cochrane and Embase was conducted. Articles relating to actual human larynx transplantations were included.
Results
Bibliography search gathered N = 10 publications related to the performance and follow-up of human laryngeal transplantations. N = 8 publications were included corresponding to N = 3 actual human larynx transplantations performed in 1998 and 2010 in the USA and in 2015 in Poland. Immunosuppression protocols, induction and maintenance strategies, rejection monitoring and history of all the three previous laryngeal grafts were detailed.
Conclusions
Beyond the surgical prowess, larynx transplantation is feasible and associated with a reasonably successful outcome when compared to other solid organ transplants. Immunosuppressive regimen protocols and technologies for the monitoring of the organ viability have evolved.
Significance
The reevaluation of this surgical option serves as the reminder of the critical necessity to implement a meticulous immunosuppression protocol when transplanting this inherently immunogenic composite organ, the larynx.
Chinese Abstract
背景：1998年、2010年、2015年及2023年成功实施了四次喉移植手术, 这仍然是声音、进食和呼吸康复的最终目标。
目的：详细记录先前成功的同种异体喉移植期间使用的免疫抑制方案。
材料和方法：对关于 PUBMED/Medline、Cochrane 和Embase的文献进行了系统审查。 其中包括与真实人类喉移植相关的文章。
结果：参考书目搜索到了 10 篇与人类喉移植效果和后续行动相关的出版物。 包括 8 篇出版物, 对应于 3 项1998 年和 2010 年在美国以及 2015 年在波兰进行的真实人类喉移植。 详细说明了免疫抑制方案、诱导和维护策略、排斥监测以及所有三个以前的喉移植物的历史记录。
结论：喉移植术除了手术技术一流外, 而且是可行的, 并且与其他实体器官移植相比, 可获得相当成功的结果。用于监测器官活力的免疫抑制方案和技术已经取得发展。
意义：对这种手术的重新评估提醒我们, 在移植喉这种固有免疫原性复合器官时, 实施细致的免疫抑制方案至关重要。
Acknowledgements
None.
Disclosure statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.