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International Journal of Neuroscience Volume 117, 2007 - Issue 1
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CHLORPYRIFOS INCREASES THE LEVELS OF HIPPOCAMPAL NMDA RECEPTOR SUBUNITS NR2A AND NR2B IN JUVENILE AND ADULT RATS

FATIH GULTEKIN School of Medicine Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey
,
INANC KARAKOYUN School of Medicine Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey
,
RECEP SUTCU School of Medicine Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey
,
EMIN SAVIK School of Medicine Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey
,
GOKHAN CESUR School of Medicine Department of Physiology, Suleyman Demirel University, Isparta, Turkey
,
HIKMET ORHAN Department of Animal Science Unit of Biometry, Suleyman Demirel University, School of Agriculture, Isparta, Turkey
&
NAMIK DELIBAS School of Medicine Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey
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Pages 47-62 | Received 31 Oct 2005, Published online: 07 Jul 2009
 
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Abstract

The present study investigated the effect of chlorpyrifos on NMDA receptor subunits NR2A and NR2B in juvenile and adult rats. Chlorpyrifos was administered with the dose of 40 and 70 mg/kg to juvenile and adult rats, respectively. Chlorpyrifos significantly inhibited the AChE activity in juvenile and adult rats (p < .05). NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p < .05). Increased NR2A and NR2B levels may reflect increased glutaminergic activity, consequently neuronal damage. In the case of neuronal damage, learning and memory could be affected negatively even though NR2A and NR2B increased.

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