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International Journal of Neuroscience Volume 117, 2007 - Issue 10
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EFFECTS OF TESTOSTERONE AND GROWTH HORMONE ON LONG-TERM RETENTION AND EXTINCTION OF A PASSIVE AVOIDANCE RESPONSE IN YOUNG AND AGED RATS

S. SCHNEIDER-RIVAS Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
,
C. PAREDES-CARBAJAL Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
,
D. MASCHER Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
,
M. ANGOA-PÉREZ Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
,
E. JARAMILLO-GONZALÉZ Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
,
G. BORGONIO-PÉREZ Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
&
S. RIVAS-ARANCIBIA Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México
 show all
Pages 1443-1456 | Received 23 Aug 2006, Published online: 07 Jul 2009
 
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Abstract

Wistar rats were divided into two blocks: young and aged. Each block was then randomly divided into the following groups: (1) Control (saline solution), (2) Growth Hormone (GH), (3) Testosterone enanthate, and (4) GH plus testosterone enanthate. Animals were trained on a one-trial passive avoidance conditioning and tested for retention 24 h after training and thereafter twice a week until the extinction response occurred. Results showed that GH, testosterone, and GH plus testosterone improved long-term memory in young rats. Both GH and testosterone delayed the extinction process in young and aged rats. The GH-testosterone interaction delayed the extinction only in young rats.

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