Tianeptine Influence on Plasmatic Catecholamine Levels and Anxiety Index in Rats Under Variable Chronic Stress After Early Maternal Separation

Abstract

The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.

Keywords:

• anxiety
• catecholamines
• early maternal separation
• plus maze
• tianeptine
• variable chronic stress