Pien Tze Huang, a Composite Chinese Traditional Herbal Extract, Affects Survival of Neuroblastoma Cells

Abstract

Pien Tze Huang is a popular Chinese medicine for liver diseases. In the investigations of possible effects of Pien Tze Huang on the central nervous system, we first studied the in vitro anti-cancer activity of Pien Tze Huang on neuroblastoma cells (SH-SY5Y) as compared with normal fibroblasts (NIH-3T3). Results showed that Pien Tze Huang significantly decreased (p < .05) cell survival of SH-SY5Y as compared to NIH-3T3. Furthermore, the decreases in cell survival of SH-SY5Y were significantly and linearly dose-dependent (p < .05) from 400 to 1,000 μg/ml. This supports further in vivo and animal studies for anti-cancer effect, neuroprotection, and theirmechanisms.

Keywords:

• anti-cancer effect
• MTT reduction test
• neuroblastoma
• Pien Tze Huang