Apolipoprotein E Genotype in Patients with Cerebrovascular Diseases and its Effect on the Disease Outcome

Abstract

A total of 100 hospitalized stroke patients and 30 healthy controls were included in a study aiming to determine the predictive role of ApoE genotype polymorphism for stroke outcome in the Turkish population. The most frequent ApoE genotype was ε3/3 reflecting Asian population polymorphic distribution. ApoE polymorphism in the Eastern Turkish population was found to be independent of stroke type, OSCP subtypes of infarction, localization of hemorrhage, severity of carotid artery stenosis, and resultant stroke outcome. Distinct polymorphic results in populations from nearby regions suggest a multifactorial pathogenesis and presence of very complex genetic factors in the development of stroke and stroke outcome.

Keywords:

• ApoE polymorphism
• cerebrovascular disease
• hemorrhagic stroke
• ischemic stroke
• outcome
• Turkish population