Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study

ABSTRACT

Purpose: To evaluate the neuroprotective effects of Dl-3-n-butylphthalide (NBP) on patients with radiation-induced brain injury, a hospital-based, clinical retrospective cohort study was conducted. Patients and methods: Data were collected on patients diagnosed with radiation-induced brain injury from January 2009 to January 2015 in Department of Neurology, Sun Yat-Sen Memorial Hospital. All patients enrolled have received cranial radiotherapy and were diagnosed with radiation-induced brain injury. Patients fulfilling certain eligibility criteria were recruited for analysis. The clinical therapeutic effects were observed and evaluated by LENT/SOMA scores before and one month after treatment in these two groups, respectively. Results: The therapeutic effects of headache (total efficiency 75.76%), eurologic deficit (total efficiency 81.58%), cognitive functions (total efficiency 77.78%) and MRI results (total efficiency 74.29%) were better in the experimental group than those in the control group (p < 0.05). Nevertheless, there was no significant difference in mood and personality changes between these two groups. Conclusions: Administration of Dl-3-n-butylphthalide, in adjunct to corticosteroid therapy, might provide a better outcome in patients with radiation-induced brain injury.

KEYWORDS:

• Radiation-induced brain injury
• radiotherapy
• Dl-3-n-butylphthalide
• neurologic function protection
• clinical study

Acknowledgments

This work was supported by Grants from Project of Product, Study and Research of Guangzhou City (No.201508020058 to Ying Peng), National Natural Science Foundation of China (No.81272197 to Ying Peng), Natural Science Foundation of Guangdong Province (No.2014A030313187 to Yi Li) and National Natural Science Foundation of China (No.81502167 to Xiaoming Rong).

Disclosure statement

The authors disclosed no conflicts of interest.

Additional information

Funding

Project of Product, Study and Research of Guangzhou City [grant number 201508020058 (Ying Peng)]; National Natural Science Foundation of China [81272197 (Ying Peng)]; Natural Science Foundation of Guangdong Province [grant number 2014A030313187 (Yi Li)]; National Natural Science Foundation of China [grant number 81502167 (Xiaoming Rong)].