Optimal vitamin D level ameliorates neurological outcome and quality of life after traumatic brain injury: a clinical perspective

Abstract

Background

Deficiency of vitamin D along with traumatic brain injury (TBI) augments the risk of injury severity. This possibly affects the therapeutic regimen prescribed for TBI which may pessimistically affects its outcome.

Methods

Studies literature search was conducted in Google Scholar and PubMed. The inclusions were studies performed clinically on both male and female. All included studies’ references were also reviewed to find any additional relevance related to this review. Studies published in English were considered for this review. This review focuses upon the incidence of vitamin D deficiency in TBI and how it affects the Quality of life of the sufferer.

Results

A total of 176 studies were reviewed and 58 were thoroughly focussed for review as they met inclusion criteria. These studies demonstrate that levels of vitamin D influence the recovery outcome after TBI. Vitamin D deficiency has been found to cause more deterioration in severe TBI than in patients with mild TBI.

Conclusion

Paucity of vitamin D significantly affects the outcome after brain injury. This clearly validates the necessity for screening of vitamin D levels in neurological deficit in order to reduce the risk of morbidity in terms of neurocognitive disorder.

Keywords:

• Vitamin D
• traumatic brain injury
• neurological outcome
• neurocognitive dysfunction

Author contributions

AC and AK: conception and design, acquisition of data, analysis and interpretation of data, and drafting the manuscript; SS: conception and design, analysis and interpretation of data, and drafting the manuscript; RS: acquisition of data, analysis and interpretation of data, and critical revision; LK: conception and design, and critical revision; SJ: conception and design, and critical revision; SS: critical revision of the manuscript; DK: conception and design, analysis.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Funding

The study was self-funding. The authors have not received any specific funding for this work.