Concomitant variations of gastric tone and duodenal motility in humans: Results of a placebo-controlled study assessing octreotide and sumatriptan

Abstract

Objective. To describe the concomitant effects of octreotide and sumatriptan on fundic tone and duodenal phase III activity. Material and methods. A double-blind study was performed in nine volunteers, studied for 2 h after receiving 50 µg octreotide, 6 mg sumatriptan or placebo. Fundic tone variations were assessed by barostat while antroduodenal motility was studied concomitantly using manometry. Results. A rapid increase in intrabag volume was observed in all but one subject after both sumatriptan and octreotide administration, while only two subjects exhibited a volume variation after placebo, p<0.01. A significant decrease in the number of phasic contractions was observed after octreotide, while sumatriptan reduced only wave amplitudes (p<0.05). A total of 13 concomitant duodenal phase III-like activities were observed in the duodenum after octreotide, 3 after sumatriptan and 4 after placebo, all followed by spontaneous fundic relaxation with disappearance of phasic contractions, p<0.05. Spontaneous phase III activities were different from phases III-like activities after octreotide in velocity and duration (p<0.05). Conclusions. Octreotide induced concomitant fundic relaxation, disappearance of phasic contractions and duodenal phase III-like activity. Sumatriptan relaxed the proximal stomach and reduced the amplitude of fundic phasic contractions without affecting concomitant antroduodenal phase III activity.

• Antroduodenal motility
• double-blind controlled study
• fundic relaxation
• octreotide
• sumatriptan