Effect of Pancreatic Enzymes in Non-Ulcer Dyspepsia

A Pilot Study

P. M. KlevelandSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

T. JohannessenSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

P. KristensenSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

I. LøgeSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

P. SandbakkenSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

J. DybdahlSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

H. PetersenSection of Gastroenterology, Dept. of Medicine, and Dept. of Community Medicine and General Practice, Regional and University Hospital of Trondheim, University of Trondheim, Trondheim, Norway

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Abstract

The symptomatic effect of pancreatic enzymes was examined in 37 patients with non-ulcer dyspepsia (NUD) recruited from general practice by means of a 24-day multi-crossover model (MCOM) including six treatment periods and five regular interchanges between pancreatic enzymes and placebo. The evaluation was based on a comparison of the enzyme-and placebo-associated symptoms and on the number of times pancreatic enzymes were associated with less symptoms than the preceding or following placebo period in individual patients. No evidence of a short-term effect of pancreatic enzymes in NUD was found.

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Effect of Pancreatic Enzymes in Non-Ulcer Dyspepsia

A Pilot Study

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Effect of Pancreatic Enzymes in Non-Ulcer Dyspepsia

A Pilot Study

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