Ulcerative colitis associated with pemphigus: a population-based large-scale study

Abstract

Background: The coexistence of pemphigus and ulcerative colitis (UC) has been described, but the association between the two entities was not examined in the past. The primary endpoint of this study was to investigate the association between pemphigus and UC.

Materials and methods: Patients with pemphigus were compared to age-, sex- and ethnicity-matched control subjects regarding the prevalence of UC in a cross-sectional study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was conducted utilizing the computerized database of Clalit Health Services.

Results: The study enrolled 1985 pemphigus patients and 9874 controls. The prevalence rate of UC was greater in patients with pemphigus than in controls (0.9% vs. 0.4%, respectively; p = .004). In a multivariate analysis pemphigus was independently associated with UC (odds ratio 1.9, 95% confidence interval 1.1–3.3, p = .034). This association was stronger among younger patients, and persisted after performing a sensitivity-analysis including only patients who were prescribed pemphigus-specific medications.

Conclusions: Pemphigus is significantly associated with UC. Thus, physicians treating patients with pemphigus should be aware of this possible association. Further research is warranted to better understand the mechanism underlying this association.

Keywords:

• Pemphigus
• ulcerative colitis
• autoimmunity
• association

Acknowledgments

Dr. Kridin, Dr. Comaneshter and Prof. Cohen had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Dr. Kridin and Dr. Zelber-Sagi. Acquisition, analysis and interpretation of data: Dr. Kridin and Dr. Zelber-Sagi. Drafting of the manuscript: Dr. Kridin and Prof. Cohen.

Critical revision of the manuscript for important intellectual content: Dr. Kridin and Prof. Cohen. Statistical analysis: Dr. Zelber-Sagi. Obtained funding: None. Administrative, technical or material support: Prof. Cohen and Dr. Comaneshter. Study supervision: Dr. Zelber-Sagi and Prof. Cohen.

Disclosure statement

The authors declare no conflict of interests. No funding was gained for the research.