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Scandinavian Journal of Infectious Diseases Volume 41, 2009 - Issue 6-7
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Case Reports

Spleen modulation of cytoadherence properties of Plasmodium falciparum

Anjanie Munasinghe From the Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo
,
Manjula Ileperuma From the Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo
,
Gayani Premawansa District General Hospital, Gampaha
,
Shiroma Handunnetti Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo
&
Sunil Premawansa From the Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo; Department of Zoology, Faculty of Science, University of Colombo, Sri LankaCorrespondence[email protected]
Pages 538-539 | Received 09 Apr 2009, Published online: 21 Jul 2009
 
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Abstract

Cytoadherence to CD36 and ICAM-1 and var gene expression of P. falciparum parasites from a splenectomized patient were studied. These parasites lacked cytoadherence and showed expression of a non-coding cDNA sequence. Hence the spleen's modulation of parasite cytoadherence by mechanisms that affect the parasite's surface antigen expression is suggested.

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