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Scandinavian Journal of Urology and Nephrology Volume 39, 2005 - Issue 5
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CASE REPORT

Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin

Tetsuo Hayashi Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, JapanCorrespondence[email protected]
, PhD , MD,
Soichiro Yoshida Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
,
Atushi Yoshinaga Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
,
Rena Ohno Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
,
Nobuyuki Ishii Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
&
Takumi Yamada Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
Pages 431-432 | Received 29 Nov 2004, Published online: 09 Jul 2009
 
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Abstract

We present two cases of infertile male patients with oligoasthenozoospermia who were receiving anti-epilepsy medication. Complete reversal of the spermatic dysfunction followed by a successful conception was achieved after discontinuation of sodium valproate, suggesting that the drug was responsible for spermatic dysfunction in these individuals.

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