Abstract
An efficient and practical route to α‐aminocarbonylketene dithioacetals 5 and α‐cyanoketene dithioacetals 6 was developed. With readily available α‐acetyl‐α‐aminocarbonyl ketene dithioacetals 4 as the starting materials, α‐aminocarbonylketene dithioacetals 5 were prepared in high yield via base‐catalyzed (sodium hydroxide) deacetylation. In the presence of POCl3 and with DMF as the solvent, α‐cyanoketene dithioacetals 6 were obtained via dehydration of 5 in excellent yield.
Acknowledgments
Financial support of this by the National Natural Science Foundation of China (NNSFC) (20272008) and the Key Grant Project of Chinese Ministry of Education (10412) are greatly acknowledged.