Selective Mono‐BOC Protection of Diamines

Abstract

A facile route for mono‐BOC protection of symmetrical and unsymmetrical diamines was developed by sequential additions of 1 mol of HCl and 1 mol of (BOC)₂O followed by neutralization.

Keywords:

• diamine
• mono‐BOC
• protection

Acknowledgments

We gratefully acknowledge the financial support from the Korea Science and Engineering Foundation (R01‐2005‐000‐10032‐0 and the Center for Bioactive Molecular Hybrids to H. J. H. and KRF‐2002‐070‐C00060 to W. K. L.). The partial support from the HUFS research grant (2006) is also gratefully acknowledged.