Synthesis of Novel N‐Morpholinoacetyl‐2,6‐diarylpiperidin‐4‐ones

Abstract

A series of N‐chloroacetyl‐2,6‐diarylpiperidin‐4‐ones (10–18) obtained from the corresponding 2,6‐diarylpiperidin‐4‐ones upon base‐catalyzed condensation with morpholine afforded N‐morpholinoacetyl‐2,6‐diarylpiperidin‐4‐ones (19–27). The synthesized compounds have been characterized by their elemental, analytical, and spectral data.

Keywords:

• chloroacetylation
• condensation
• morpholine
• piperidin‐4‐ones

Acknowledgment

We are thankful to K. Pandiarajan, head, Department of Chemistry, Annamalai University, for the facilities provided. One of the authors, S. K., is grateful to University Grants Commission and Council of Scientific and Industrial Research, New Delhi, India, for financial support in the form of major research projects. We also thank NMR Research Centre, Indian Institute of Science (IISc), Bangalore, for providing all the NMR facilities to record NMR spectra.