Abstract
This report describes the synthesis of 4‐substituted‐ and 1,4‐disubstituted‐4‐hydroxypyrrolidin‐2‐ones by cyclization of intermediate γ‐aminoesters prepared from alkylbenzylamines, α‐bromoketones, and lithio ethyl acetate.
Keywords:
Acknowledgments
The authors thank Wheaton College for financial support and Douglass A. Klumpp, Northern Illinois University, for mass spectral analysis.