Abstract
Pd(MeCN)2Cl2/PCy3 was found to be an efficient catalytic system for the Suzuki–Miyaura cross‐couplings of aryl chlorides with arylboronic acids under solvent‐free conditions. Furthermore, the presence of the conventional solvents had deleterious effect on the reaction. In the presence of Pd(MeCN)2Cl2, PCy3, and TBAF (tetra‐n‐butylammonium fluoride), a number of aryl chlorides including heteroaryl chlorides were coupled with arylboronic acids or heteroarylboronic acids smoothly to afford the corresponding products in moderate to excellent yields.
Acknowledgment
The authors thank the National Natural Science Foundation of China (No. 20572020), Fok Ying Dong Education Foundation (No. 101012), the Key Project of Chinese Ministry of Education (No. 206102), Scientific Research Fund of Hunan Provincial Education Department (No. 05B038), and Hunan Provincial Natural Science Foundation of China (No. 05JJ1002) for financial support.