Microwave‐Assisted One‐Pot Synthesis of 2‐(Substituted phenyl)‐1H‐benzimidazole Derivatives

Abstract

A series of 2‐(substituted phenyl)‐1H‐benzimidazole derivatives with various 5‐and 6‐position substituents (‐H, ‐CH₃, ‐CF₃) were synthesized via microwave irradiation using a short synthetic route and Na₂S₂O₅ as oxidant. This simple, fast, and efficient preparation of benzimidazole derivatives has been developed using readily available and inexpensive reagents (aldehydes and 1,2‐phenylenediamines) under solvent‐free conditions.

Keywords:

• benzimidazole
• microwave‐assisted synthesis
• solvent‐free reaction

Acknowledgments

This work was supported in part by a grant from Programa de Mejoramiento de Profesorado, Secretaria de Educaciōn Pūblica (PROMEP–SEP), UAEMOR‐PTC‐131 (Gabriel Navarrete‐Vazquez (GNV)). We are grateful to Victoria Labastida and Maria Medina from the Chemical Research Centre (CIQ), Autonomous University of Morelos State (UAEM), for the determination of all mass spectra.