Efficient Method for the Synthesis of Benzimidazoquinazoline Derivatives with Three‐Point Diversity

CDRI Communication No. 7150.

Abstract

An efficient strategy for the preparation of a novel heterocyclic ring system of benzimidazoquinazolines with three‐point diversity has been described. The compounds were obtained by treating o‐phenylene diamines with o‐nitrobenzaldehyde to give benzimidazoles, followed by reduction of the nitro group to give an amine. Derivatization of the resulting amine with isothiocyanates followed by in situ cyclodesulfurization at rt furnished the title compounds in high yields and purities.

Keywords:

• benzimidazoquinazoline
• o‐phenylene diamines
• prototropic tautomerism
• quinazoline ring

Acknowledgment

B. Saha and S. Sharma are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, for financial support.

Notes

CDRI Communication No. 7150.