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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 18
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Original Articles

Convenient Formal Synthesis of (±)‐Paroxetine

Subhash P. Chavan Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, IndiaCorrespondence[email protected]
,
Dushant A. Khobragade Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India
,
Ashok B. Pathak Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India
&
Uttam R. Kalkote Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India
Pages 3143-3149 | Received 29 Jan 2007, Published online: 10 Sep 2007
 
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Abstract

A formal total synthesis of antidepressant (±)‐paroxetine employing a solvent‐free Heck reaction is disclosed.

Acknowledgments

D. A. K. and A. B. P. thank Council for Scientific and Industrial Research (CSIR), New Delhi, India, for providing fellowships. We are grateful to Shinji Yamada and C. R. D. Correia for kindly providing spectral data of the authentic samples.

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