Abstract
A fast and highly convenient procedure for the formation of Fmoc‐protected amino aldehydes from the corresponding alcohols using 1.1 equiv. of IBX in the presence of dimethylsulfoxide (DMSO) is discussed. This procedure leads to the clean synthesis of Fmoc‐amino aldehydes in excellent yields with less than 1% epimerization and with no chromatography required for purification.
Acknowledgment
The authors are grateful to Arthur Grieb for chiral HPLC analysis.