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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 20
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Original Articles

Synthesis of Benzo[b]thiophene Carboxamides Connected to 4‐Arylpiperazines through a Benzylic Spacer: Potential Ligands with 5‐HT1A Binding Affinity

Hernán Pessoa‐Mahana Faculty of Chemical and Pharmaceutical Sciences, Department of Organic and Physical Chemistry, University of Chile, Santiago, ChileCorrespondence[email protected]
,
R. Acevedo Faculty of Chemical and Pharmaceutical Sciences, Department of Organic and Physical Chemistry, University of Chile, Santiago, Chile
,
Ramiro Araya‐Maturana Faculty of Chemical and Pharmaceutical Sciences, Department of Organic and Physical Chemistry, University of Chile, Santiago, Chile
,
Claudio Saitz Faculty of Chemical and Pharmaceutical Sciences, Department of Organic and Physical Chemistry, University of Chile, Santiago, Chile
&
C. David Pessoa‐Mahana Faculty of Chemical, Department of Pharmacy, Pontificia Universidad Católica de Chile, Santiago, Chile
Pages 3559-3567 | Received 28 Mar 2007, Published online: 05 Oct 2007
 
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Abstract

New benzothiophene arylpiperazine derivatives 8 (a–f) were synthesized as potential serotoninergic agents with 5‐HT1A receptor affinity. Preparation of the derivatives was performed by treating N‐[2‐(chloromethyl)phenyl]‐4,7‐dimethoxybenzo[b]thiophene‐2‐carboxamide (7) with a series of substituted 4‐arylpiperazines.

Acknowledgments

We thank Proyectos Fondecyt 1050289 and Proyecto Cepedeq–Facultad, Facultad de Ciencias Químicas y Farmacéuticas Universidad de Chile, Santiago, Chile.

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