Abstract
(2S)‐6‐Fluoro‐4‐oxo‐3,4‐dihydro‐2H‐chromene‐2‐carboxylic acid, a key intermediate of Fidarestat, was synthesized from natural chiral pool D‐mannitol. Its structure was confirmed by optical analyses, elemental analyses, and IR, 1H NMR, and ESI‐MS spectra.
Acknowledgment
This work was supported by the National Natural Science Foundation of China (No. 30672537).