Abstract
An efficient and environmentally friendly synthesis of tetrahydro‐β‐carboline hydrochlorides via Pictet–Spengler reaction was described. Tryptamine hydrochlorides were used as the reactant and no additional acid catalyst was needed. This reaction was completed within 2.5–9 min in good yield.
Acknowledgments
The present work was supported by Specialized Research Fund for the Doctoral Program of Higher Education P.R.C. (No. 20060316006) and “The Six Top Talents” of Jiangsu Province (No. 06‐C‐23).